Arsenic as a Global Pollutant - Arsenic as a Global Pollutant Tiffany Berg March 26th, 2011 Health effects of arsenic poisoning Keratosis Internal tumors Cancers of the skin, liver, bladder, and lungs. Lead (Pb) has been used by humans for at least 7000 years, because it is widespread, easy to extract, and easy to work with. Arsenic - . Mechanism of arsenic poisoning Adrian Bumstead, Xiao Qi Li, Jessica So, Jin (Donna) Yang PHM142 Fall 2015 Instructor: Dr. Jeffrey Henderson Overall - try to keep the text to a minimum (the presentation guideline for the cardio Arsenic poisoning( acute, subacute and chronic) 1. Arsenic. why is it called arsenic?. 25 year old vietnamese lady unable to communicate due to language, Arsenic Poisoning in tube wells in bangladesh - By: lauren jones & david pinigis. Create stunning presentation online in just 3 steps. Poisoning - By kristin hoffpauer , courtney maccallum , sarah plante , sammi pedigo. Arsenic - . -3. acute toxicity acute, short, severe course, adverse effects occurring within a short time of, Arsenic - . by, jeremy rubert. Arsenic poisoning in Bangladesh Fluorosis • Tooth discoloration and decay • Crippling skeletal damage Arsenicosis • Skin pigmentation changes and skin thickening (hyperkeratosis) • Cancer of … © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. In the 15th and 16th centuries, the Italian family of Borgias used arsenic as their favorite poison for political This a special article from Telugudoctors.co.in; Hope you find it useful and informative. o vervie w. efficiency chemical structures uses problems, Poisoning - . • Arsenic depositions in the brain and spinal cord can lead to developmental disabilities, and cognitive impairments. There are more than 8,000 villages in Bangladesh where more than 80 percent tube-wells are arsenic The patient, a chemist by profession, prepared this amount of arsenic trioxide in his factory laboratory using a commercial solution of arsenic trichloride (AsCl3) as a base. p.861-864. Chronic arsenic poisoning is due to repeated or continuous exposure to arsenic compounds, which leads to an accumulation of arsenic in the body. small systems implementation strategy & exemptions. • Inhibits p53, Treatment of Arsenic Poisoning • Chelation therapy removes heavy metals • Dimercaprol • First antidote • Intramuscular Injection (painful) • Narrow therapeutic window • DMSA • Currently used • Fewer side effects • Can be administered orally Dimercaprol Dimercaptosuccinic acid (DMSA) Dimercaptosuccinic acid (DMSA), Summary • Symptoms include headache, drowsiness, diarrhea, vomiting, bloody urine, convulsions, changes in fingernail pigmentation • Enters body via inhalation and/or ingestion and mainly distributes to liver • Inorganic arsenate is metabolized in liver by methylation to MMA and DMA. poisons. • Carcinogenic due to oxidative stress, inhibition of p53, genotoxicity, altered DNA repair mechanisms and tumor promotion • “Arsenite” - Trivalent (As3+): Reacts with reacts with thiols and sulfhydryl groups • Inhibits GSH Reductaseblocks of GSH production Oxidative stress and production of free radicals • Inhibits Pyruvate Dehydroxygenase decreased activity in Citric Acid Cycle decreased ATP production and Gluconeogenesis • “Arsenate” - Pentavalent (As5+): replaces phosphate groups because of similar molecular structure). We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Arsenic poisoning: A national health security issue Arsenic exposure in Bangladesh is widespread and it involves thousands of wells. Johnston and Heijnen : Safe Water Technology for Arsenic Removal 3 should be considered, so that the workload of women and girls is not unduly increased. Patient went into shock and finally was admitted in the ICU
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. +5. arsenic poisoning in tube. It is the common environmental toxicant and is found in soil, water, and air. Slide 7- ppt slide no 7 content not found Arsenic Exposure and Toxicology: A Historical Perspective Hughes, M. (2002). Alsevier Inc. Rosen, B. Arsenic toxicity and methods of detection. Cancer Research. loveland tech4good luke whitaker / may 27, 2014. arsenic detection techniques. as atomic number: 33 relative mass: 74.92 metalloid grey or yellow or black, Poisoning - . peter worcester a period. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Get powerful tools for managing your contents. If you continue browsing the site, you agree to the use of cookies on this website. His blood picture and abdomen radiography were as in the images. He also used to complain of tingling and numbness over his hands and foot.
He gives history of having consumed water from his work place for the past 3 days as he forgot to carry his own bottle and has been suffering from severe gastroenteritis ever since. Clipping is a handy way to collect important slides you want to go back to later. food air water. Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. Arsenic poisoning, or arsenicosis, happens when a person takes in dangerous levels of arsenic. poisoning. Acute Poisoning: Symptoms of acute intoxication usually occur within 30 minutes of ingestion but may be delayed if arsenic is taken with the food. chronic arsenic poisoning among workers (17). Stools were initially Rice water type but later became bloody
On examination he had some nail changes, sensory loss and dermatitis like picture. Wayne State University School of Medicine [PDF Document]. What atomic number:33 element symbol:as element name:arsenic atomic mass:75. See our User Agreement and Privacy Policy. Your advice would be useful in perfecting our future slides. Long-term exposure to arsenic can also lead to cancer, possibly affecting the lungs, bladder and Distribution • The largest quantity of arsenic is found in the liver. You can change your ad preferences anytime. structures, physical and chemical properties, Poisoning - . arsenic. Lead Poisoning. used : rat poison found: food, water. Arsenic is a natural semi-metallic chemical that is found all over the world in groundwater. The three main sources of exposure are occupational exposure, natural contaminants of drinking water (from some deep water wells) and ancient Chinese medicinal remedies containing arsenic. sources . Homeostasis and Toxicology of Non-Essential Metals. properties. Arsenic round the world: a review. substance which when introduced into body in relatively small amounts causes in structural damage, Arsenic Rule - . Arsenic is a natural component of the earth’s crust and is widely distributed throughout the environment in the air, water and land. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Looks like you’ve clipped this slide to already. Arsenic - . Toronto: Oxford UP, 2009. References Caballero, B.(2009). Arsenic: toxicity, oxidative stress and human disease. elment info. A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. arsenic - . Arsenic Trade Show Treatment Options Overview The main considerations when selecting a treatment technology include: Water quality characteristics (including pH levels and initial concentrations of iron, As(III), and As Now customize the name of a clipboard to store your clips. this element's name was derived from " arsenikon. summarized the environmental behaviour of arsenic, with particular emphasis on sources, distribution, and accumulation of arsenic in the Australianence of SOS-Arsenic: Private Iniciative against Poisoning of Ground Water in Bangladesh The arsenic hazard in Bangladesh villagers now appeared as a ‘real disaster', affecting thousands physically, physiologically, mentally and economically; it is intensifying malnutrition, … Those who survive arsenic trioxide poisoning may develop encephalopathy or severe peripheral neuropathies. (2011). Retrieved from Lecture Notes Online Website: http://mstc.csmu.edu.tw/ezcatfiles/mstc/img/img/466/961008-BarryPhilipRosen.pdf Sears, M. E. (2013). What is Arsenic . 6 th period by: katelyn keller brianna leslie tiffany goulart. Request PDF | On Jan 1, 2000, D. N. Guha Mazumder published Chapter 4 : Diagnosis and treatment of chronic arsenic poisoning | Find, read and cite all the research you need on ResearchGate China lead poisoning(2009) Zamfara lead poisoning(Mar-June 2010): About 163 deaths due to illegal extraction of ore by villagers in Anka & Bukuyyum LGA’s. Re-cently, Smith et al. Toxicology Letters 133:1-16 Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C.J., Valko, M. (2010). Arsenic has been used since 3000 BC. USES: primarily in the production of glass and semiconductors, in wood and hide preservation, as an additive of metal alloys In the past arsenic was used as weed killer, rodenticide, in chemical warfare pigments and enamels. http://dx.doi.org/10.1155/2013/219840 Sullivan, John B. and Gary R. Krieger. Arsenic contamination of groundwater is a form of groundwater pollution which is often due to naturally occurring high concentrations of arsenic in deeper levels of groundwater. everyone reacts differently. Journal of Applied Toxicology. 31:95-107. arsenic compliance in perspective water, Arsenic - . poisoning. 33. 33. as arsenic 75. arsenic. 2 ppm 1-40 ppm 0.01 – 800 ppb As high as 40,000 in hot springs 2.38 – 65 ppb Some Arsenic Uses/Anthropogenic Sources • Smelting of metals time scale: hours and days. Guide to Nutritional Supplements. danger rangers video. However, symptoms of chronic arsenic poisoning from ingestion of contaminated water are typically observed only after 10 or more years of exposure. Absorption • Soluble and acidic arsenic compounds are readily absorbed in the stomach • Inorganic Arsenic compounds can also be sequestered on mucosal linings, leading to irritations and a concentration gradient that aids in the absorption of Arsenic compounds. food sources. • Recommended treatment is Dimercaptosuccinic acid (DMSA). arsenic is a solid, liquid , and a gas!. The Scientific World Journal, 2013, 13 Pages. EvironmnetalChemistry.com. A 47-year-old man had an episode of severe respiratory failure after acute intoxication with arsenic. It acts on glycolysis, TCA cycle and on Pyruvate dehydrogenase complex. It is highly toxic in its inorganic form.People are exposed to elevated levels of inorganic arsenic through drinking contaminated water, using contaminated water in food preparation and irrigation of food crops, industrial processes, eating contaminated food and smoking tobacco.Long-term exposure to inor… See our Privacy Policy and User Agreement for details. arsenic. reactor shut down!. atomic number is 33 atomic mass is 75 family: 15 nitrogen. Customer Code: Creating a Company Customers Love, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). Chelation: Harnessing and Enhancing Heavy Metal Detoxification- a review. Arsenic is highly toxic in its inorganic form. by: marquise washington. albertus magnus (1193-1280), a german philosopher and theologian, was the first to state that arsenic has a, Arsenic - . belongs to family number 15 has 5, Mercury and Arsenic poisoning - . Arsenic toxicity is a global health problem affecting many millions of people. Arsenic Poisoning - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. the poison of kings. +3. Long-term poisoning. Arsenic Detection Techniques - . As 33 74.99. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. 62:3893-3903 Mcintyre, D, O. Linton, T, K. (2011). two kinds of poisoning have been identified by the national safety, Poisoning - . ryan clark & candace williams. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi... No public clipboards found for this slide. He was admitted 5 h later. prepared by muhammad hashim. PHM142H1-F October 9, 2013. New technologies require behavioral change on the part of the user, thus A 43-year-old male attempted suicide in July, 2001, by drinking 54 g of arsenic trioxide (As2O3). (2013). Metabolism • Main organ for arsenic metabolism is the liver, Metabolism continued Step 1 • Inorganic pentavalent arsenate is reduced to trivalent arsenite in the blood stream before entering the cells • Can occur non-enzymatically in the presence of a thiol such as glutathione (GSH), Metabolism continued Step 2 • Methylation to monomethylarsonic acid (MMA) and to dimethyl- arsinic acid (DMA) is enzymatic, requiring S- adenosylmethionine (SAM) and a methyltransferase • MMA and DMA are excreted in the urine (thousandfold less-potent as mutagenic agents than inorganic arsenic) • Methylation has long been considered the main route of detoxification, but there is growing literature supporting other methods such as transport and antioxidant defenses, Mechanism of Action of (As3+) • Reacts with thiol-containing molecules (R-SH) • Arsenite inhibits GSH Reductase by interacting with critical thiol groups • Blocks production of GSH (glutathione, important antioxidant) causing increased free radicals and oxidative damage • Increased production of ROS such as superoxide radical, singlet Oxygen, hydroxyl radicals, hydrogen peroxide, Mechanism of Action of (As3+) • Inhibits lipoicacid (a dithiol) which is an important cofactor for Pyruvate Dehydroxygenase (PDH) • As [Acetyl CoA] decreases Citric Acid Cycle activity decrease, causing: • Decreased ATP production • Decreased Gluconeogenesis (synthesis of glucose from carbohydrates, fatty acids, proteins, etc) Function of PyruvateDehydroxygenase: Oxidize Pyruvate to Acetyl CoA before Citric Acid Cycle Arsenic binds to Lipoid Acid-PDH to form 6-member ring Lipoic Acid-PDH, Arsenate resembles Inorganic Phosphate Competitively inhibits phosphate for active site in G3P-Dehydroxygenase Replaces phosphate in many biochemical reactions in cellular respiration ATP ADP-arsenate (arsenolytic mechanism – uncouples ATP formation) Glucose-6-Phosphate Glucose-6-Arsenate Glyceraldehyde-3-Phosphate Glyceraldehyde-3-Arsenate Mechanism of Action of (As5+) Inorganic Phosphate is chemically similar to Inorganic Arsenate, Inhibition of Glyceraldehyde-3-Phosphate dehydrogenase, Arsenic is a Carcinogen • Associated with oxidative stress, cell arrest in the G2/M phase, chromosomal abnormalities, and DNA aneuploidy. Natural Arsenic Levels Crystalline Rock Soil Ground Water Surface Water Avg. 33 2,8,18,5 as arsenic 74.92160. electron diagram. seafood –, Poisoning - . Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. Summary Exposure to heavy metals such as mercury, lead, iron, and arsenic is harmful to the human body and can potentially cause both acute symptoms (e.g., local irritation, gastroenteritis, and pneumonia) and longterm effects (e.g., abnormal physical development, cancer, damage to the central nervous system, and kidney). Arsenic poisoning acts on different metabolic pathways of glucose metabolism. Treatment of arsenic poisoning in acute toxic poisonings needs to begin quickly; treatment involves removal of arsenic by dialysis , chelating agents, replacement of red blood cells , and if ingested, bowel cleansing. PHM142H1-F October 9, 2013. Arsenic is present as a contaminant in many traditional remedies. Arsenic, element 33, has a long and nefarious history; its very name has become synonymous with poison. 74.92106. Arsenic toxicity and potential mechanisms of action. (2002). jonathan kernaghan. A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. Mechanisms of Action of Arsenic Trioxide. • Metabolized to toxic form of As3+ , MMA(III) before entering cells • ADP forms ADP-arsenate instead of ATP; Glucose-6-Arsenate instead of G6P; Glyceraldehyde-3-arsenate instead of G3P. Talanta, 58, 201-235. http://dx.doi.org/10.1016/S0039-9140(02)00268-0 Miller, W., Schipper, H., Lee, S., et al. A brief presentation on Arsenic poisoning encompassing 40 slides - also included is a quiz on toxicology at the end. Welcome to Click to edit Master subtitle style ARSENIC POISONING Click to edit Master subtitle style Amir Sadaula (01) Arjun Pandit (02) Bikas Puri (03) Bishwo Bandhu Pokharel (04) As 33 74.99. Print. not anticipated! | PowerPoint PPT On arrival he was pale and diaphoretic, but his vital signs were normal. poisoning. Arsenic - . PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. poisoning. Arsenic Poisoning. as. 2,8,18,5. information. morgan dunn stevie turner. An element found in many natural sources, PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson Arsenic Poisoning PHM142H1-F October 9, 2013 Presented by: NirojanBalachandran SarangaSreeskantharajan Kimberly Stobo TianQi Wang, As 33 • 74.99 What is Arsenic • An element found in many natural sources • Many uses including: • Agriculture (Wood preservative) • Medicine (Arsenic trioxide treatment for certain leukemia) • Arsenic recognized as a carcinogen • Arsenic poisoning most commonly through sources such as contamination of groundwater • Many cases throughout the world, Sign and Symptoms • Headaches • Drowsiness • Diarrhea • Vomiting • Bloody urine • Convulsions • Changes in fingernail pigmentation (leukonychiastriata) • Coma Death, How Arsenic Enters the Body • Mainly through inhalation and ingestion • To a lesser extent, through the skin • Enters cells via Aquaporin channels. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. Symptoms of arsenic poisoning, or arsenicosis, can include skin lesions, swollen limbs and loss of feeling in the hands and legs. What causes chronic arsenic poisoning? Dr Kaleem Khan Assistant Professor JNMCH 2. Arsenic PowerPoint Presentations you can use in your safety training programs. Retrieved from http://library.concordia.ca/help/howto/apa.php#online Hughes,M, F. Beck, B,D et al. 135 xe 10 6 b. Arsenic - Laura stanton. ARSENIC POISONING A. Features of the initial clinical presentation included nausea, vomiting, and diarrhea, acute psychosis, diffuse skin rash, and marked pancytopenia. 149, Arsenic-Gallium - . Furthermore, it was observed that new cases of human poisoning … Diagnosis of arsenic poisoning is made by determining inorganic and organic levels of arsenic in the blood and urine. claire m. waggoner aquatic toxicology. – A free PowerPoint PPT presentation (displayed as a Flash group 15, metalloid (category/group) germanium, gallium, it sublimates, Arsenic - . Mandal, B. K., & Suzuki, K. T. (2002). 1. Physical Properties. If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. It is a high-profile problem due to the use of deep tube wells for water supply in the Ganges Delta , causing serious arsenic poisoning to large numbers of people. Arsenic Poisoning. and signs of arsenic poisoning in human beings may increase with a de crease in arsenic level in the drinking water source. We have tried to make it as attractive, brief and informative as possible. dr esther tsang august 2011. case 1. properties. If you continue browsing the site, you agree to the use of cookies on this website. Arsenic poisoning 1. Contaminated water used for drinking, food preparation and irrigation of food crops poses the greatest threat to public health from arsenic. 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